Prepositions are a nightmare for anyone who wants to learn English, but here are some general rules (taken from http://www.englishgrammar.org/general-rules-prepositions):
Use ‘in’ for countries and big towns. She was born in New Zealand.
I live in Mumbai.
Use ‘at’ for addresses.
Are you still at that address? We live at D 23, MG Road.
Use ‘in’ for position inside a three dimensional space.
The cat is in the kitchen.
Use ‘on’ for position on the surface of something.
There is something on the roof.
Put the books on the table.
Use ‘to’ and ‘into’ to show direction.
He went to work.
The child fell into the well.
Use ‘till’ to indicate time.
I waited till 6 o’clock.
Use ‘since’ to indicate the starting point of something.
I have been waiting since morning.
Use ‘for’ to indicate duration.
It rained for two hours.
We have been living in this city for three years.
Use ‘from’ to indicate the source.
She comes from a small town.
Use ‘to’ to indicate the destination.
He went to America.
Use ‘between’ to indicate position between two or more clearly defined people or objects.
The child sat between his father and parents.
Use ‘among’ to indicate position among more than two people or objects.
She sat among the children.
Use ‘with’ to indicate the instrument and ‘by’ to indicate the agent.
He killed the spider with a stone.
The spider was killed by the boy.
Use ‘beside’ to mean ‘by the side of’.
The boy sat beside his mother.
